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End using DEPAKOTE, and contact your Health care service provider or get professional medical support right away when you create any of such indicators of the serious pores and skin reaction: fever

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Suicidal feelings or steps could be because of points apart from medicines. When you've got suicidal ideas or steps, your healthcare company may check for other will cause.

People with mitochondrial sickness caused by a specific DNA mutation are at a heightened possibility of acute liver failure and resultant Demise.

2. Depakote might damage your unborn infant. If you're taking Depakote in the course of pregnancy for any clinical condition, your child is in danger for severe beginning defects that have an impact on the Mind click here and spinal cord (for example spina bifida or neural tube defects). These defects can start out in the very first month, even before you decide to know you happen to be pregnant.

Experiments have discovered that individuals who take antiepileptic prescription drugs like valproate have suicidal thoughts or behaviors as many as 2 times as typically than individuals who acquire placebo (inactive medication).

Depakote ER tablets and Depakote delayed-launch tablets can also be applied to stop migraine problems.

Carbapenem Antibiotics A clinically substantial reduction in serum valproic acid concentration is documented in clients acquiring carbapenem antibiotics (such as, ertapenem, imipenem, meropenem; it's not an entire record) and could result in lack of seizure Command.

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have or Imagine you do have a genetic liver issue caused by a mitochondrial ailment for example Alpers-Huttenlocher syndrome.

very low physique temperature (hypothermia). A drop in Your whole body temperature to below ninety five°F can take place through treatment with DEPAKOTE. Phone your Health care service provider For those who have any of the subsequent symptoms:

Ahead of having Depakote, explain to your Health care provider about all of your current healthcare ailments such as for those who: have or have experienced liver problems.

Methotrexate Methotrexate may perhaps lower serum valproate degrees and potentially lead to enhanced frequency of seizures or bipolar indications.